What is the mechanism of action of Denosumab?  What are some of the major side effects?   Denosumab is a monoclonal antibody which binds to RANKL preventing RANK from interacting with it.  Some of the major side effects are hypophosphotemia, decreased appetite, fatigue, weakness, and dermatitis.

What are a few risk factors for the development of osteomalacia?   Inadequate vitamin D intake and little exposure to sunlight are causes of osteomalacia.

What are some lifestyle modifications that can be made to reduce osteoporosis risk and/or reduce its progression?   Some lifestyle modifications consist of quit smoking, stop drinking alcohol, exercising regularly, and consuming a well balanced diet.